PF 431396( PF-431396 | PF 431396 | PF431396 )

Catalog No. M19031 CAS No. 717906-29-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PF 431396
Note

Research use only, not for human use.
Brief Description

PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).
Description

PF-431396 is a potent and selective focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively).
In Vitro

——
In Vivo

——
Synonyms

PF-431396 | PF 431396 | PF431396
Pathway

Others
Target

Other Targets
Recptor

FAK| PYK2
Research Area

Endocrinology
Indication

——

CAS Number

717906-29-1
Formula Weight

506.5
Molecular Formula

C22H21F3N6O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

n1c(nc(c(c1)C(F)(F)F)NCc1c(cccc1)N(C)S(=O)(=O)C)Nc1ccc2c(c1)CC(=O)N2
Chemical Name

N-Methyl-N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide

1. Han S, et al. J Biol Chem. 2009, 284(19), 13193-13201.

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