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PF 431396

CAS No. 717906-29-1

PF 431396 ( PF-431396; PF 431396; PF431396 )

Catalog No. M19031 CAS No. 717906-29-1

PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 67 In Stock
25MG 133 In Stock
50MG 235 In Stock
100MG 402 In Stock
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Biological Information

  • Product Name
    PF 431396
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).
  • Description
    PF-431396 is a potent and selective focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively).
  • Synonyms
    PF-431396; PF 431396; PF431396
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    FAK; PYK2
  • Research Area
    Endocrinology
  • Indication
    ——

Chemical Information

  • CAS Number
    717906-29-1
  • Formula Weight
    506.5
  • Molecular Formula
    C22H21F3N6O3S
  • Purity
    98%
  • Solubility
    ——
  • SMILES
    n1c(nc(c(c1)C(F)(F)F)NCc1c(cccc1)N(C)S(=O)(=O)C)Nc1ccc2c(c1)CC(=O)N2
  • Chemical Name
    N-Methyl-N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Han S, et al. J Biol Chem. 2009, 284(19), 13193-13201.
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